Ciliary neurotrophic factor protects retinal structure against hypergravity stimulation with short time and high +Gz value in rat
نویسندگان
چکیده
Objective: To investigate the effects of hypergravity on retinal structure in rat. Methods: Retinal structure and protein expression were examined by hematoxylin and eosin stain, immunohistochemistry and Western blot in the Sprague-Dawley® rats induced by hypergravity with short arm centrifuge (+10 Gz/3 min). Results: Retinal structure had no substantial change after hypergravity stimulation, but the expression levels of glial fibrillary acidic protein and ciliary neurotrophic factor were significantly increased by hypergravity stimulation. Conclusion: Hypergravity induced the expression levels of ciliary neurotrophic factor, which protect retinal structure against hypergravity stimulation with short time and high +Gz value in rat.
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